3-Amino-1-propanesulfonic acid Chemical Properties

Melting point:

293 °C (dec.)(lit.)

Density 

1.202 (estimate)

refractive index 

1.5130 (estimate)

storage temp. 

2-8°C

solubility 

Water (Slightly)

pka

1.06±0.50(Predicted)

form 

Crystalline Powder

color 

White to slightly blue

LogP

-4.555

CAS DataBase Reference

3687-18-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

1

HS Code 

29049090

MSDS

• Language:English Provider:Homotaurine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

3-Amino-1-propanesulfonic acid Usage And Synthesis

Description

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

Chemical Properties

White Powder

Uses

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

Definition

ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .

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