3,4-Dichlorobenzylamine Chemical Properties

Melting point:

332-333 °C(Solv: N,N-dimethylformamide (68-12-2))

Boiling point:

80-82 °C (0.6 mmHg)

Density 

1.32 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.578(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

pka

8.56±0.10(Predicted)

form 

Liquid

Specific Gravity

1.322

color 

Clear colorless to light yellow

Sensitive 

Air Sensitive

BRN 

508818

CAS DataBase Reference

102-49-8(CAS DataBase Reference)

EPA Substance Registry System

Benzenemethanamine, 3,4-dichloro- (102-49-8)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34

Safety Statements 

23-26-36/37/39-45

RIDADR 

UN 2735 8/PG 3

WGK Germany 

3

Hazard Note 

Irritant/Air Sensitive

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214990

MSDS

• Language:English Provider:3,4-Dichlorobenzylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,4-Dichlorobenzylamine Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

3,4-Dichlorobenzylamine is a benzylamine compound. Benzylamines are a class of small-molecule compounds with simple structures, widely present in the biological world, with extremely important physiological and pharmacological activities, and are widely used in the research and development of antibacterial drugs. For example, the antifungal drugs terbinafine and butenafine all have the structure of benzylamine.

Synthesis

Using 3,4-dichlorobenzyl azide (5 mmol, 1.01 g) as raw material, dichloromethane (25 mL) was added to a 100 mL reaction flask and a dichloromethane (25 mL) solution of boron tribromide (20 mmol, 5.00 g) was slowly added dropwise under nitrogen protection. After the dropwise addition, the reaction was stirred at 25 °C for 6 hours. Upon completion of the reaction, the reaction was quenched by the addition of methanol (25 mL) and stirring was continued for 0.5 hours. After the reaction solution was clarified, the reaction solution was concentrated by rotary evaporator. The resulting crude product was recrystallized using a mixed solvent of methanol/ether to give the title compound 3,4-dichlorobenzylamine in white solid form in 89% yield (0.778 g).

References

[1] Patent: CN108409580, 2018, A. Location in patent: Paragraph 0044; 0045; 0046

3,4-Dichlorobenzylamine(102-49-8)Related Product Information

• Tetrachlorophthalimide
• Pigment Geen 7
• 4-Ethoxybenzamide
• 3,4-DICHLOROBENZAMIDE
• (3,4-Dichlorobenzyl)methylamine
• 4,4',4''-TRIS(4,5-DICHLOROPHTHALIMIDO)TRITYL BROMIDE
• Piperonylamine
• Veratrylamine
• 3,4-DICHLOROBENZENE-1-CARBOHYDRAZIDE
• 3,4-Dichlorobenzylamine
• 2-(4-Methoxybenzylamino)pyridine
• 1-Benzylpiperazine
• Pigment Green 36
• LORGLUMIDE
• DL-LAUDANOSINE
• Fluorexon
• 4-Methoxybenzamide
• (+)-Bicuculline