2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

≤14 mg/ml in DMSO

form 

solid

color 

white to off-white

Water Solubility 

Soluble in water (supplied pre-dissolved at a concentration of 5mM)

InChIKey

HVOVBTNCGADRTH-WBLDMZOZSA-N

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT Usage And Synthesis

Uses

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections, type I diabetes induced rats and astrocyte?neuron coculture. It has also been used as a synthetic ATP analog in isotonic E3 medium.

General Description

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.

Biological Activity

Prototypic P2X 7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC 50 = 0.7 μ M in HEK 293 cells). Exhibits partial agonist activity at P2X 1 (pEC 50 = 8.7) and P2Y 1 receptors and can be used as a photoaffinity label for ATPase.

Biochem/physiol Actions

2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist. It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors. Useful as a photoaffinity label for proteins and enzymes that bind ATP.

storage

-20°C

2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT(112898-15-4)Related Product Information

• Adenosine triphosphate
• 4-Acetylbenzoic acid
• 1-AMINO-3-BENZYLOXY-PROPAN-2-OL
• METHYL 4-ACETYLBENZOATE
• 4-BROMOBENZHYDROL
• 2'-Deoxyadenosine 5'-triphosphate
• ETHYL 4-ACETYLBENZOATE
• Benzoic acid, 4-benzoyl-, methyl ester
• 3'-O-ACETYL-2'-DEOXYADENOSINE
• METHYL 4-BENZYLBENZOATE
• 3'-DEOXYADENOSINE 5'-TRIPHOSPHATE SODIUM SALT
• TRIETHYLAMMONIUM PHOSPHATE
• ETHYL 4-BENZYLBENZOATE
• METHYL 4-ETHYLBENZOATE
• 4-ETHYLBENZOIC ACID ETHYL ESTER
• Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)
• 3'-O-Methyl-D-adenosine
• 4-CARBOETHOXYBENZOPHENONE