Boc-D-Valine Chemical Properties

Melting point:

164-165 °C

alpha 

6.25 º (c=1, acetic acid)

Boiling point:

357.82°C (rough estimate)

Density 

1.1518 (rough estimate)

refractive index 

6 ° (C=1, AcOH)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO, Methanol

form 

Solid

pka

4.01±0.10(Predicted)

color 

White

BRN 

2050408

Major Application

peptide synthesis

InChI

InChI=1S/C10H19NO4/c1-6(2)7(8(12)13)11-9(14)15-10(3,4)5/h6-7H,1-5H3,(H,11,14)(H,12,13)/t7-/m1/s1

InChIKey

SZXBQTSZISFIAO-SSDOTTSWSA-N

SMILES

C(O)(=O)[C@@H](C(C)C)NC(OC(C)(C)C)=O

CAS DataBase Reference

22838-58-0(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29241990

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Boc-D-Valine Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

tert-Butoxycarbonyl-D-valine is used in the preparation of selective CCR1 antagonists in the treatment of rheumatoid arthritis. Also used in the preparation of antileishmanial agents.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

D-Valine, 20 mL of ethyl acetate and 10 mL of tetrahydrofuran were added to the reaction bottle, 4.2 g (19.3 mmol) of Boc anhydride was added to the reaction system, and stirred at room temperature for 6 h. The progress of the reaction was detected by thin-layer chromatography, and waited for the end of the reaction. The reaction solution was evaporated to dryness, and saturated ammonium chloride solution was added to the residual solution to separate the organic phase, which was then washed with saturated saline, dried, filtered and evaporated to dryness to obtain Boc-D-valine.

Boc-D-Valine(22838-58-0)Related Product Information

• Valine
• tert-Butyl carbazate
• N-Carbobenzyloxyglycine
• D-Valine
• tert-Butanol
• L-Valine
• BOC-D-Cysteine (Boc-D-Cys-OH )
• Boc-L-Glutamic acid 5-benzylester
• BOC-D-PHE-OSU
• 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
• Methyl N-(tert-butoxycarbonyl)-L-threoninate
• Boc-Hyp-OH
• Boc-L-serine methyl ester
• BOC-GUANIDINE
• N-Boc-L-valine
• BOC-D-ALPHA-T-BUTYLGLYCINE
• Boc-alpha-Cyclohexyl-D-glycine
• Boc-D-isoleucine