9-PHENYLXANTHEN-9-OL Chemical Properties

Melting point:

158-161 °C(lit.)

Boiling point:

377.3°C (rough estimate)

Density 

1.1160 (rough estimate)

refractive index 

1.5510 (estimate)

form 

powder to crystal

pka

12.76±0.20(Predicted)

color 

White to Almost white

CAS DataBase Reference

596-38-3(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

8

HS Code 

2932.99.7000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

9-PHENYLXANTHEN-9-OL Usage And Synthesis

Chemical Properties

WHITE TO PALE YELLOW CRYSTALS OR CRYST. POWDER

Uses

Antioxidant agent-15 (Compound 4) is a potent antioxidant inhibition activity, with the IC50 of 15.44 nM. Antioxidant agent-15 inhibits tumor cell growth in Hela, Hep G2 and Caco-2 cells, with the IC50 of 395.26, 400.4 and 24.6 nM, respectively[1].

Purification Methods

Dissolve hydroxypixyl in AcOH and add H2O whereby it separates as colourless prisms. It is slightly soluble in CHCl3, soluble in *C6H6 but insoluble in pet ether. It sublimes on heating. UV in H2SO4: 450nm max ( 5620) and 370nm ( 24,900) and the HClO4 salt in CHCl3 has 450 ( 404) and 375nm ( 2420). max [Sharp J Chem Soc 2558 1958, Bünzly & Decker Chem Ber 37 2983 1904, Chattopadhyaya & Reece J Chem Soc, Chem Commun 639 1978, Gomberg & Cone Justus Liebigs Ann Chem 370 142 1909, Beilstein 17 I 80, 17 II 161, 17 III/IV 1704, 17/4 V 675.]

References

[1] Abualhasan M, et al. Biological Evaluation of Xanthene and Thioxanthene Derivatives as Antioxidant, Anticancer, and COX Inhibitors. ACS Omega. 2023;8(41):38597-38606. DOI:10.1021/acsomega.3c05695

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