APRAMYCIN
APRAMYCIN Basic information
- Product Name:
- APRAMYCIN
- Synonyms:
-
- APRAMYCIN
- 3,7-trideoxy-7-(methylamino)-d-glycero-alpha-d-allo-octadialdo-1,5:8,4-dipyra
- ambylan
- C01555
- ApryMycin
- O-4-Amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-D-streptamine
- Apramycin (Nebramycin II)
- CS-1309
- CAS:
- 37321-09-8
- MF:
- C21H41N5O11
- MW:
- 539.58
- EINECS:
- 253-460-1
- Product Categories:
-
- Peptide Synthesis/Antibiotics
- Mol File:
- 37321-09-8.mol
APRAMYCIN Chemical Properties
- Boiling point:
- 823.0±65.0 °C(Predicted)
- Density
- 1.56
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.91±0.70(Predicted)
- color
- Crystals
- EPA Substance Registry System
- Apramycin (37321-09-8)
APRAMYCIN Usage And Synthesis
Chemical Properties
Crystals. Sol in water; sltly sol in lower alcs.
Uses
Antibacterial.
Uses
Apramycin is used in treatment and prevention of nephrotoxin-induced kidney injuries.
Definition
ChEBI: An aminoglycoside that is 2-deoxystreptamine that is substituted on the oxygen at position 4 by an (8R)-2-amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino -D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl) group.
Safety Profile
When heated to decomposition itemits acrid smoke and irritating fumes.
in vivo
Apramycin (200 mg/kg/d, s.c., 9 d) demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) dose-dependently reduces bacterial burden in the kidneys between 2-5 log10 and in blood between 2-3 log10 for neutropenic model of Staphylococcus aureus septicemia mice[2].
Apramycin (50 mg/kg/d, s.c., 21 d) induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)[3].
| Animal Model: | M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice [2] |
| Dosage: | 200 mg/kg/d |
| Administration: | Subcutaneousinjection (s.c.) for 9 d |
| Result: | Showed a 2.4-log10 CFU reduction and better antituberculous activity compared to Amikacin (1.8-log10 reduction). |
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