3-(Trifluoromethyl)benzaldehyde Chemical Properties

Boiling point:

83-86 °C30 mm Hg(lit.)

Density 

1.301 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.465(lit.)

Flash point:

155 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

1.301

color 

Clear colorless to very slightly orange

Sensitive 

Air Sensitive

BRN 

2327537

InChIKey

NMTUHPSKJJYGML-UHFFFAOYSA-N

CAS DataBase Reference

454-89-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 3-(trifluoromethyl)-(454-89-7)

EPA Substance Registry System

Benzaldehyde, 3-(trifluoromethyl)- (454-89-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)

WGK Germany 

3

F 

10-23

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29130000

MSDS

• Language:English Provider:alpha,alpha,alpha-Trifluoro-3-tolualdehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(Trifluoromethyl)benzaldehyde Usage And Synthesis

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY ORANGE LIQUID

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-╬│-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 426, 1946 DOI: 10.1021/ja01207a024

General Description

Aldol reaction of 3-(trifluoromethyl)benzaldehyde with hydroxyacetone in the aldolase antibody 38C2-ionic liquid system has been investigated.

3-(Trifluoromethyl)benzaldehyde(454-89-7)Related Product Information

• 2-Methylbenzotrifluoride
• Benzaldehyde
• 3-Aminobenzotrifluoride
• 2-(Trifluoromethyl)benzoic acid
• (Trifluoromethyl)trimethylsilane
• 3-(Trifluoromethyl)anisole
• 3-(Trifluoromethyl)benzoyl chloride
• 3-Trifluoromethylphenol
• 3-(Trifluoromethyl)phenylacetone
• 3-(Trifluoromethyl)benzoic acid
• Trifluoromethanesulfonic acid
• p-Tolualdehyde
• 4-(Trifluoromethoxy)benzaldehyde
• 4-(Trifluoromethyl)benzoic acid
• alpha,alpha,alpha-Trifluoro-o-toluoyl chloride
• 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
• 1-NAPHTHALEN-2-YL-ETHYLAMINE
• 3-(3-METHYLPHENYL)PROPIONIC ACID