Basic information Uses Safety Supplier Related

3-(Trifluoromethyl)benzaldehyde

Basic information Uses Safety Supplier Related

3-(Trifluoromethyl)benzaldehyde Basic information

Product Name:
3-(Trifluoromethyl)benzaldehyde
Synonyms:
  • m-Trifluoromethoxy benzaldehyde
  • 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-3-tolualdehyde
  • Alpha-Trifluoro-M-tolualdehyde
  • 3-(TrifluoroMethyl)benzaldehyde, 97% 25GR
  • 3-(TrifluoroMethyl)benzaldehyde, 97% 5GR
  • 3-Formylbenzotrifluoride, alpha,alpha,alpha-Trifluoro-m-tolualdehyde
  • 3-(three fluoroMethyl)benzeneforMaldehyde
  • Between the three groups in benzene forMaldehyde
CAS:
454-89-7
MF:
C8H5F3O
MW:
174.12
EINECS:
207-228-1
Product Categories:
  • Benzotrifluoride Series
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • 3-(Trifluoromethyl)benzaldehyde
  • bc0001
Mol File:
454-89-7.mol
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3-(Trifluoromethyl)benzaldehyde Chemical Properties

Boiling point:
83-86 °C30 mm Hg(lit.)
Density 
1.301 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.465(lit.)
Flash point:
155 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless to very slightly orange
Specific Gravity
1.301
Sensitive 
Air Sensitive
BRN 
2327537
InChIKey
NMTUHPSKJJYGML-UHFFFAOYSA-N
CAS DataBase Reference
454-89-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 3-(trifluoromethyl)-(454-89-7)
EPA Substance Registry System
Benzaldehyde, 3-(trifluoromethyl)- (454-89-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)
WGK Germany 
3
10-23
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29130000

MSDS

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3-(Trifluoromethyl)benzaldehyde Usage And Synthesis

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY ORANGE LIQUID

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-╬│-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 426, 1946 DOI: 10.1021/ja01207a024

General Description

Aldol reaction of 3-(trifluoromethyl)benzaldehyde with hydroxyacetone in the aldolase antibody 38C2-ionic liquid system has been investigated.

3-(Trifluoromethyl)benzaldehyde Preparation Products And Raw materials

Preparation Products

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