4-Bromo-2-fluoroaniline Chemical Properties

Melting point:

40-42 °C

Boiling point:

103-108 °C (13 mmHg)

Density 

1.6196 (rough estimate)

refractive index 

1.4710 (estimate)

Flash point:

220 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.50±0.10(Predicted)

form 

Crystalline Mass, Powder, Crystals and/or Chunks

color 

Beige to light brown to brown-gray or gray

BRN 

2081089

Stability:

Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.

InChI

InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

InChIKey

GZRMNMGWNKSANY-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(Br)C=C1F

CAS DataBase Reference

367-24-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Bromo-2-fluoroaniline(367-24-8)

Safety Information

Hazard Codes 

Xi,T,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39-36

RIDADR 

UN2811

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

MSDS

• Language:English Provider:4-Bromo-2-fluoroaniline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Bromo-2-fluoroaniline Usage And Synthesis

Chemical Properties

solid

Uses

4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration.

Synthesis

To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 ??C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline.

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