3-Pyrid-4-ylbenzaldehyde Chemical Properties

Melting point:

48 °C

Boiling point:

341.8±25.0 °C(Predicted)

Density 

1.147±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

4.72±0.26(Predicted)

color 

Beige

CAS DataBase Reference

208190-04-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36/37/38-36

Safety Statements 

22-26-36/37/39

HS Code 

2933399990

3-Pyrid-4-ylbenzaldehyde Usage And Synthesis

Synthesis

Step 1: In a 2L three-necked round-bottomed flask, a nitrogen inert atmosphere was established and maintained. A solvent mixture of 2-propanol/water (800mL/40mL) with pyridine-4-boronic acid (30g, 244mmol, 1.0 eq.), Na2CO3 (77.3g, 729mmol, 3.0 eq.), Pd(OAc)2 (5.46g, 24.3mmol, 0.1 eq.), PPh3 (12.75g, 48.7 mmol, 0.2 equiv) and m-bromobenzaldehyde (45 g, 243 mmol, 1.0 equiv). The reaction mixture was placed in an oil bath at 80 °C and the reaction was stirred for 48 hours. After completion of the reaction, the solid was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:1, v/v) to give 30 g of 3-(pyridin-4-yl)benzaldehyde, the product was in the form of an orange oil.

References

[1] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2761 - 2766
[2] Patent: WO2013/16807, 2013, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2015/127559, 2015, A1. Location in patent: Page/Page column 31

3-Pyrid-4-ylbenzaldehyde(208190-04-9)Related Product Information

• (+/-)-NICOTINE
• 3-Pyridinecarboxaldehyde
• 2-Nitrobenzaldehyde
• p-Anisaldehyde
• 4-Hydroxybenzaldehyde
• Benzaldehyde
• Salicylaldehyde
• 4-Dimethylaminobenzaldehyde
• 3-PYRID-2-YLBENZALDEHYDE
• 3-PYRID-3-YLBENZALDEHYDE
• 4-PYRID-3-YLBENZALDEHYDE
• 3-PYRIDIN-4-YL-BENZOIC ACID
• 3-Pyrid-4-ylbenzaldehyde
• pyridylaldehyde
• METHYL 3-(4-PYRIDINYL)BENZOATE
• Isoschumanniophytine