2-AMINO-3-IODO-5-NITROPYRIDINE Chemical Properties

Melting point:

231-236 °C

Boiling point:

391.7±42.0 °C(Predicted)

Density 

2.229±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

0.41±0.49(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-43

Safety Statements 

26-36/37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

2-AMINO-3-IODO-5-NITROPYRIDINE Usage And Synthesis

Uses

Useful starter in azaindole chemistry.

Synthesis

General procedure for the synthesis of 2-amino-3-iodo-5-nitropyridine from 2-amino-5-nitropyridine: 5-nitropyridin-2-amine (14 g, 100 mmol), potassium iodide (16.6 g, 100 mmol) and potassium iodate (10.7 g, 50 mmol) were dissolved in dilute sulfuric acid (2 N, 200 mL). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the pH was adjusted slowly by adding sodium hydroxide solution (5 N, 80 mL) to about 10. The resulting solid product was collected by filtration, washed sequentially with deionized water and ethanol and finally dried under vacuum. The target compound 2-amino-3-iodo-5-nitropyridine (25 g, 94% yield) was obtained. The structure of the product was characterized by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 6.80-8.40 (br s, 2H), 8.57 (d, J = 2.4 Hz, 1H), 8.84 (d, J = 2.4 Hz, 1H); MS (ESI) m/z 264 [M+H]+.

References

[1] Synthesis, 2005, # 15, p. 2503 - 2506
[2] Patent: WO2010/32, 2010, A1. Location in patent: Page/Page column 78-79
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3853 - 3860
[4] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 56-57
[5] Organic Process Research and Development, 2015, vol. 19, # 9, p. 1282 - 1285

2-AMINO-3-IODO-5-NITROPYRIDINE(25391-56-4)Related Product Information

• 2-Amino-3-bromo-5-methylpyridine
• 3-iodo-5-(trifluoromethyl)-2-pyridinylamine
• 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine
• 2-Amino-3-bromo-5-nitropyridine
• METHYL 6-AMINO-5-BROMONICOTINATE
• 6-AMino-5-iodo-nicotinic acid Methyl ester
• 2-AMINO-3-IODO-5-METHYLPYRIDINE
• methyl 6-amino-5-chloronicotinate
• 3-Chloro-5-(trifluoromethyl)pyridin-2-amine
• 6-AMINO-5-CHLORO-NICOTINONITRILE
• 2-AMINO-3-CHLORO-5-NITROPYRIDINE
• 2-AMINO-5-IODO-3-NITROPYRIDINE
• 5-IODO-PYRIDIN-3-YLAMINE
• 2-AMINO-3-IODO-5-NITRO-6-METHYLPYRIDINE
• 3-Iodopyridin-2-amine
• 2-AMINO-3-IODO-5-NITROPYRIDINE