Desonide
Desonide Basic information
- Product Name:
- Desonide
- Synonyms:
-
- PREDNACINOLONE
- DESONIDE
- 1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
- (11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
- 16-alpha-hydroxyprednisole-16,17-acetonide
- 17-acetonide,16-alpha-hydroxy-prednisolone-1
- d-2083
- steroderm
- CAS:
- 638-94-8
- MF:
- C24H32O6
- MW:
- 416.51
- EINECS:
- 211-351-6
- Product Categories:
-
- SPORANOX
- Hormone Drugs
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- API
- Mol File:
- 638-94-8.mol
Desonide Chemical Properties
- Melting point:
- 272-274?C
- Boiling point:
- 580.1±50.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 12.87±0.10(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 638-94-8(CAS DataBase Reference)
MSDS
- Language:English Provider:Desonide
Desonide Usage And Synthesis
Chemical Properties
Off-White Solid
Originator
Tridesilon,Dome,US,1972
Uses
Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
Uses
antifungal
Uses
Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
Definition
ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.
brand name
Desowen (Galderma); Tridesilon (Perrigo).
Therapeutic Function
Antiinflammatory
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Desonide(638-94-8)Related Product Information
- (r)-budesonide
- Ciclesonide
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- 14,15-Dehydro Budesonide
- 9α-BroMobudesonide
- 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers)
- LY2228820
- Meprednisone
- Dienogestrel
- Clopidogrel Bisulfate
- LY 2157299
- Budesonide
- Di-Norbudesonide (Mixture of DiastereoMers)
- 9,11-Anhydrobudesonide
- 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
- (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione
- 1,2-Dehydrobudesonide
- Budesonide Sulfate SodiuM (Mixture of DiastereoMers)