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Desonide

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Desonide Basic information

Product Name:
Desonide
Synonyms:
  • PREDNACINOLONE
  • DESONIDE
  • 1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
  • (11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
  • 16-alpha-hydroxyprednisole-16,17-acetonide
  • 17-acetonide,16-alpha-hydroxy-prednisolone-1
  • d-2083
  • steroderm
CAS:
638-94-8
MF:
C24H32O6
MW:
416.51
EINECS:
211-351-6
Product Categories:
  • SPORANOX
  • Hormone Drugs
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • API
Mol File:
638-94-8.mol
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Desonide Chemical Properties

Melting point:
272-274?C
Boiling point:
580.1±50.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
form 
Solid
pka
12.87±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
638-94-8(CAS DataBase Reference)
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Safety Information

HS Code 
2937290000
Toxicity
LD50 in rats (mg/kg): 93 s.c. (Phillips)

MSDS

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Desonide Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Tridesilon,Dome,US,1972

Uses

Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.

Uses

antifungal

Uses

Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).

Definition

ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.

Indications

Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.

Manufacturing Process

Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.

brand name

Desowen (Galderma); Tridesilon (Perrigo).

Therapeutic Function

Antiinflammatory

DesonideSupplier

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