2-(DIFLUOROMETHOXY)ANILINE Chemical Properties

Boiling point:

205 °C(lit.)

Density 

1.272 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.505(lit.)

Flash point:

199 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

liquid

pka

2.93±0.10(Predicted)

Specific Gravity

1.272

color 

Clear, dark red

BRN 

2718520

InChI

1S/C7H7F2NO/c8-7(9)11-6-4-2-1-3-5(6)10/h1-4,7H,10H2

InChIKey

CGNAIUUCOVWLLL-UHFFFAOYSA-N

SMILES

Nc1ccccc1OC(F)F

CAS DataBase Reference

22236-04-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

20/21/22

Safety Statements 

36

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222990

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-(DIFLUOROMETHOXY)ANILINE Usage And Synthesis

Uses

2-(Difluoromethoxy)aniline is used as an organic intermediate.

Synthesis

Iron powder (5 eq.) was added to a solution of 2-(difluoromethoxy)nitrobenzene (1 eq.) in MeOH/MeCOOH (1:1). The reaction mixture was heated at 50 ??C under N2 The reaction mixture was heated at 50 ??C for 3 hours under N2 . The reaction mixture was concentrated under vacuum. To the residue, EtOAc (100 mL) and 1 m NaOH were added. (50mL) to the residue. Remove the precipitate by centrifugation. The aqueous layer was separated. Extract the aqueous layer with EtOAc (3 ?? 50 mL). Combine the organic layer and extract. Dry the combined organic layers and extract with MgSO 4. Extraction. Filter the combined organic layer and extract. Concentrate the combined organic layer and extract in vacuum.

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