4-IODOPYRIDIN-2-AMINE Chemical Properties

Melting point:

163-164 °C

Boiling point:

309.4±27.0 °C(Predicted)

Density 

2.055±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

5.92±0.11(Predicted)

color 

Off-white

Safety Information

HS Code 

2933399990

4-IODOPYRIDIN-2-AMINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-iodo-2-aminopyridine from 2-fluoro-4-iodopyridine was as follows: 2-fluoro-4-iodopyridine (10.00 g, 43.50 mmol) was mixed with ammonium hydroxide (10 mL) in DMSO (20 mL), and the reaction was stirred for 40 h at 100 °C. After completion of the reaction, water (100 mL) was added to the reaction mixture and the precipitate was collected by filtration to afford the target product 4-iodo-2-aminopyridine (Compound 10a) as a brown solid in 90% yield (8.62 g). Mass spectrometry result: 221 (M + H)+.

References

[1] Patent: WO2017/211303, 2017, A1. Location in patent: Page/Page column 43
[2] Patent: US2011/39893, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: US2003/199511, 2003, A1. Location in patent: Page/Page column 33

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