Mito-apocynin (C11)
Mito-apocynin (C11) Basic information
- Product Name:
- Mito-apocynin (C11)
- Synonyms:
-
- Mito-apocynin (C11)
- (11-((4-Hydroxy-3-methoxybenzoyl)oxy)undecyl)triphenylphosphonium bromide
- Mito apocynin (C11),Mitoapocynin (C11),Mito-apocynin (C-11)
- CAS:
- 1254044-38-6
- MF:
- C37H44BrO4P
- MW:
- 663.63
- Mol File:
- 1254044-38-6.mol
Mito-apocynin (C11) Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- White to off-white
Mito-apocynin (C11) Usage And Synthesis
Uses
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1].
in vivo
Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice[1].
| Animal Model: | LRRK2R1441G mice[1] |
| Dosage: | 3 mg/kg |
| Administration: | Oral gavage; 3x/wk from 3 months of age until 15 months |
| Result: | Markedly improved the coordinated motor function and olfactory function. |
References
[1] Dranka BP, et al. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. Neurosci Lett. 2014 Nov 7;583:159-64. DOI:10.1016/j.neulet.2014.09.042
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