N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 Chemical Properties

solubility 

Soluble in Water, DMSO, DMF, DCM

N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 Usage And Synthesis

Description

N-(azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media.

Uses

N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5(2107273-42-5)Related Product Information

• N-(m-PEG4)-N'-(PEG2-acid)-Cy5
• N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride
• N-PEG3-N'-(azide-PEG3)-Cy5
• N-(m-PEG4)-N'-(azide-PEG4)-Cy7
• N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5