SINOVA SL-02580 Chemical Properties

Melting point:

236 °C

Density 

1.328

storage temp. 

Store at -20°C

solubility 

insoluble in H2O; insoluble in EtOH; ≥20.2 mg/mL in DMSO

form 

solid

pka

11.99±0.40(Predicted)

SINOVA SL-02580 Usage And Synthesis

Description

BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (K_d= 21.1 nM; K_i = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.

Uses

BMS 806 is a small molecular inhibitor of HIV-1 virus which blocks the interaction between gp120 and CD4 cells.

target

CD4-gp120 interactions

References

[1] wang t1, zhang z, wallace ob, deshpande m, fang h, yang z, zadjura lm, tweedie dl, huang s, zhao f, ranadive s, robinson bs, gong yf, ricarrdi k, spicer tp, deminie c, rose r, wang hg, blair ws, shi py, lin pf, colonno rj, meanwell na. discovery of 4-benzoyl-1-[(4-methoxy-1h- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (r)-methylpiperazine (bms-378806): a novel hiv-1 attachment inhibitor that interferes with cd4-gp120 interactions. j med chem. 2003 sep 25;46(20):4236-9.

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