Temocapril hydrochloride Chemical Properties

Melting point:

196-2000C (dec)

alpha 

25D +47.7° (c = 1 in DMF)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

110221-44-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

Toxicity

LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike)

Temocapril hydrochloride Usage And Synthesis

Description

Temocapril is a novel ACE inhibitor marketed in Japan for the treatment of hypertension. Temocapril is three times more potent than enalapril by oral administration, and has a long duration of action. It is characterized by a rapid onset of action resulting from a fast conversion of temocapril to the active metabolite diacid. Unlike most ACE inhibitors which are excreted mainly through the kidneys, temocapril is excreted predominantly through the biliary route indicating that temocapril is especially useful for treating hypertensive patients with renal dysfunction. The potential usefulness of temocapril in the treatment of congestive heart failure has been reported.

Chemical Properties

White To Off-White Solid

Originator

Sankyo (Japan)

Uses

Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.

Uses

angiotensin-converting enzyme inhibitor (ACE-I)

Definition

ChEBI: Temocapril hydrochloride is a dipeptide.

brand name

Acecol

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