Epinastine hydrobromide Chemical Properties

Melting point:

284-286°

storage temp. 

Sealed in dry,Room Temperature

InChI

InChI=1S/C16H15N3.BrH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

InChIKey

ADPMHRDERZTFIN-UHFFFAOYSA-N

SMILES

N12C(N)=NCC1C1C=CC=CC=1CC1C=CC=CC2=1.Br

Epinastine hydrobromide Usage And Synthesis

Application

Clinical studies have shown that, at the same dosage, epinastine hydrochloride is significantly more effective than other second-generation histamine H1 receptor antagonists such as terfenadine, astamiva, and ketotifen, and also has a lower incidence of central sedation and cardiotoxicity. Therefore, the market demand for epinastine hydrochloride is substantial, making its synthesis necessary. Literature searches reveal that publicly available patents and literature use 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azapyridine (Ⅳ) as a key intermediate in epinastine synthesis, which is cyclized with cyanogen bromide to yield epinastine. Epinastine hydrobromide is also a synthetic intermediate for epinastine.

Epinastine hydrobromide(127786-29-2)Related Product Information

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