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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Basic information

Product Name:
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
Synonyms:
  • 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid)
  • 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid]
  • 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid)
  • phosgenated
  • N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea
  • 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid)
  • N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea
  • 6,6'-ureylenbis-1-naphthol-3-sulfonic acid
CAS:
134-47-4
MF:
C21H16N2O9S2
MW:
504.49
EINECS:
205-142-9
Product Categories:
  • Intermediates of Dyes and Pigments
Mol File:
134-47-4.mol
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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Chemical Properties

Density 
1.798±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 83.33 mg/mL (165.18 mM)
form 
Solid
pka
-0.17±0.40(Predicted)
color 
Light brown to brown
CAS DataBase Reference
134-47-4(CAS DataBase Reference)
EPA Substance Registry System
7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)
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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Usage And Synthesis

Uses

7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (cas# 134-47-4) is a pharmacologically active compound capable of selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase, and inhibition of shikimate dehydrogenase and shikimate kinase in shikimate pathway of Helicobacter pylori.

Preparation

7,7' -Urylenebis(4-hydroxynaphthalene-2- sulfonic acid) [134-47-4] , J acid urea, carbonyl J acid, is produced by reacting the sodium salt of J acid with phosgene in aqueous solution at 30℃ and maintaining alkalinity with sodium carbonate. After being heated to 80℃, the product is salted out with sodium chloride (yield ca. 100 %). It is used to produce C.I. Direct Orange 26; C.I. Direct Reds 4, 14, 23, and 80; and C.I. Direct Brown 112.

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