Cefditoren Chemical Properties

Density 

1.75

pka

2.43±0.50(Predicted)

form 

Solid

color 

Light yellow to yellow

Cefditoren Usage And Synthesis

Uses

Cefditoren is an orally active antibiotic with broad-spectrum antibacterial activity, capable of inhibiting both Gram-negative and Gram-positive bacteria. It has a MIC50 of 0.25-0.5 mg/L against Streptococcus pneumoniae strains. Cefditoren is effective against respiratory tract infections and skin infections[1][2][3].

Definition

ChEBI: A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the ce hem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, ommunity-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

References

[1] Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Cefditoren. 2023 Aug 15. PMID:30000384
[2] Giuliano S, et al. Cefditoren: a clinical overview. New Microbiol. 2023 Feb;46(1):9-17. PMID:36853812
[3] Sempere J, et al. A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004-20 in Spain. J Antimicrob Chemother. 2022 Mar 31;77(4):1045-1051. DOI:10.1093/jac/dkab482

Cefditoren(104145-95-1)Related Product Information

• Cefditoren pivoxil
• Cefoxitin
• Cefovecin Sodium
• Cefoxitin sodium
• (6R,7R)
• Ceftezole sodium
• Cefotetan
• Cefoselis
• Cefmenoxime
• Cefdinir
• 4-Methyl-5-vinylthiazole
• Cefditoren
• 7-AVCA
• (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid