butizide Chemical Properties

Melting point:

214-217°C

Boiling point:

562.7±60.0 °C(Predicted)

Density 

1.4221 (rough estimate)

refractive index 

1.6100 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.01±0.40(Predicted)

color 

White to Yellow

butizide Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Saltucin,Boehringer Mannheim,W. Germany,1961

Uses

Diuretic and antihypertensive.

Definition

ChEBI: Butizide is a benzothiadiazine.

Manufacturing Process

Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.

Therapeutic Function

Diuretic, Antihypertensive

butizide(2043-38-1)Related Product Information

• Propantheline bromide
• mebutizide
• butizide
• CYCLOTHIAZIDE
• Cyclopenthiazide
• 2-AMINO-N-BUTYLBENZENESULFONAMIDE
• Hydrochlorothiazide
• ethiazide
• 2-amino-N-propylbenzenesulfonamide