Basic information Safety Supplier Related

butizide

Basic information Safety Supplier Related

butizide Basic information

Product Name:
butizide
Synonyms:
  • 6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • butizide
  • Buthiazide
  • Thiabutazide
  • Eunephran
  • S-3500
  • Saltucin
  • Su-6187
CAS:
2043-38-1
MF:
C11H16ClN3O4S2
MW:
353.85
EINECS:
218-048-8
Product Categories:
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
2043-38-1.mol
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butizide Chemical Properties

Melting point:
214-217°C
Boiling point:
562.7±60.0 °C(Predicted)
Density 
1.4221 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
pka
9.01±0.40(Predicted)
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butizide Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Saltucin,Boehringer Mannheim,W. Germany,1961

Uses

Diuretic and antihypertensive.

Manufacturing Process

Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.

Therapeutic Function

Diuretic, Antihypertensive

butizideSupplier

J & K SCIENTIFIC LTD.
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