Ethyl Biscoumacetate
Ethyl Biscoumacetate Basic information
- Product Name:
- Ethyl Biscoumacetate
- Synonyms:
-
- DI(4-oxi-cymarinyl-3)
- Pelentan
- Trombarin
- Trombil
- Trombolysan
- 2,2-bis(2-hydroxy-4-keto-chromen-3-yl)acetic acid ethyl ester
- ethyl 2,2-bis(2-hydroxy-4-oxochromen-3-yl)acetate
- ethyl 2,2-bis(2-hydroxy-4-oxo-chromen-3-yl)ethanoate
- CAS:
- 548-00-5
- MF:
- C22H16O8
- MW:
- 408.36
- EINECS:
- 208-940-5
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 548-00-5.mol
Ethyl Biscoumacetate Chemical Properties
- Melting point:
- 177-182° and mp 154-157°
- Boiling point:
- 448.92°C (rough estimate)
- Density
- 1.3259 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- pKa 7.5 (Uncertain)
- color
- White
- Water Solubility
- 54.31mg/L(temperature not stated)
Ethyl Biscoumacetate Usage And Synthesis
Chemical Properties
White, crystalline solid; odorless; bitter taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.
Originator
Tromexan,Geigy,US,1950
Uses
Anticoagulant.
Uses
Medicine (anticoagulant).
Definition
A synthetic derivative of bishydroxycoumarin.
Manufacturing Process
7 g of benzotetronic acid are dissolved in 750 cc of water at boiling
temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl
alcoholate are added. After a short while the liquid becomes turbid and
gradually a white deposit is separated. The deposit is filtrated and dried in
vacuo. The melting point is 172°C to 174°C; after recrystallization from
methyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animal
charcoal precipitated by means of hydrochloric acid, and recrystallized from
methyl alcohol. The melting point is 153°C to 154°C.
Therapeutic Function
Anticoagulant
Synthesis
Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy- 3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.
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Ethyl Biscoumacetate(548-00-5)Related Product Information
- Ethyl Biscoumacetate
- ETHYL 2-METHYL-3-PENTENOATE
- 5-PHENOXY-N-VALERIC ACID
- trans-Styrylacetic acid
- 3-BUTENE-1,2,3-TRICARBOXYLIC ACID
- (E)-Ethylidenesuccinic acid
- 4-PHENOXY-N-BUTYRIC ACID ETHYL ESTER
- coumetarol
- Dimethyl itaconate
- TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE
- DICUMAROL
- 4-HYDROXY-3-METHYL-CHROMEN-2-ONE
- 3-methyl-4-phenyl-3-butenoic acid