4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Chemical Properties

Melting point:

150°C

Boiling point:

465.9±14.0 °C(Predicted)

Density 

1.132±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml

form 

Solid

pka

4.90±0.30(Predicted)

color 

White to off-white

BRN 

5568831

EPA Substance Registry System

1-Naphthaleneacetic acid, 4-cyclohexyl-.alpha.-methyl- (71109-09-6)

Safety Information

WGK Germany 

3

Toxicity

LD50 orally in rat: 400 mg/kg (Godfroid)

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Propionic acid type non-steroidal anti-inflammatory drug (NSAID).

Definition

ChEBI: A racemate composed of equal amounts of (R)- and (S)-vedaprofen. Used for control of pain and inflammation particularly associated with chronic musculoskeletal disorders and soft tissue trauma in dogs and horses and for tr atment of pain due to horse colic.

Biological Activity

Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) th at has been found to have antimicrobial activity. Vedaprofen is primarily used as a veterinary analgesic and anti-inflammatory for arthritis and pain. Its anti-inflammatory activity is due to cyclooxygenase inihbition, while its antimicrobial activity is less certain. Vedaprofen can kill B. subtilis by permeabilizing its membrane. Other studies have shown vedaprofen can target the Escherichia coli DNA polymerase III β subunit.

4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid(71109-09-6)Related Product Information

• 4-cyclohexylphenylacetic acid
• (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID
• 4-ISOPROPYLPHENYLACETIC ACID
• (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID
• NAPHTHYL ACETIC ACID
• 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE
• 2-(4-butylphenyl)acetate
• 2-Naphthaleneethanol
• 4-cyclohexyl-alpha-methylnaphthalene-1-acetic acid
• HOMO CUMINIC ALDEHYDE 50
• 1-Naphthaleneacetic acid
• 4-Pentylphenyl acetic acid
• 4-N-BUTYLPHENETHYL ALCOHOL
• hexaprofen
• p-isopropylphenethyl alcohol