ACETYL COENZYME A (C2:0) LITHIUM
ACETYL COENZYME A (C2:0) LITHIUM Basic information
- Product Name:
- ACETYL COENZYME A (C2:0) LITHIUM
- Synonyms:
-
- ACETYL COENZYME A (C2:0) LITHIUM
- Acetyl coenzyme A trilithium salt,Acetyl-S-CoA Li3
- Coenzyme A, S-acetate,lithium salt (8CI,9CI)
- Acetyl-CoA, Acetyl-S-CoA Li3
- adenosine, 5'-O-[[[[[(3R)-4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl]oxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), trilithium salt
- Acetyl-CoA (lithium salt)
- Acetyl-S-CoA,Li
- Acetyl coenzyme A lithium salt[A2181]
- CAS:
- 32140-51-5
- MF:
- C23H39LiN7O17P3S
- MW:
- 817.52
- Mol File:
- 32140-51-5.mol
ACETYL COENZYME A (C2:0) LITHIUM Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: soluble100mg/mL, clear, colorless
- form
- powder
- color
- White to off-white
- Water Solubility
- H2O: soluble 100mg/mL, clear, colorless
- Stability:
- Hygroscopic
- InChIKey
- FTRFBNATWBKIQU-JHJDYNLLSA-K
ACETYL COENZYME A (C2:0) LITHIUM Usage And Synthesis
Uses
Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA.
Biochem/physiol Actions
Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea.
in vivo
Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3]. Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4].
IC 50
Human Endogenous Metabolite
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