β-Hydroxypyruvic acid
β-Hydroxypyruvic acid Basic information
- Product Name:
- β-Hydroxypyruvic acid
- Synonyms:
-
- 3-hydroxy-2-oxopropanoic acid
- β-hydroxypyruvic acid
- 3-HYDROXY-2-OXOPROPIONICACID
- Decanoic acid, ester with 2-ethyl-2-(hydroxymethy)-1,3-propanediol octanoate
-Hydroxypyruvic acid - 3-Hydroxypyruvate
- hydroxypyruvic aci
- 3-HYDROXYPYRUVIC ACID
- CAS:
- 1113-60-6
- MF:
- C3H4O4
- MW:
- 104.06
- Mol File:
- 1113-60-6.mol
β-Hydroxypyruvic acid Chemical Properties
- Melting point:
- 202℃ (ethanol )
- Boiling point:
- 252.9±23.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3(Predicted)
- FEMA
- 3843 | 3-HYDROXY-2-OXOPROPIONIC ACID
- storage temp.
- 2-8°C
- solubility
- 10mg/mL in PBS, pH7.2
- pka
- 2.19±0.54(Predicted)
- form
- Solid
- color
- Off-white to light brown
- Odor
- at 1.00 % in propylene glycol. sour radish cabbage
- Odor Type
- sour
- JECFA Number
- 635
- LogP
- -2.04
Safety Information
- Hazard Codes
- C
- Risk Statements
- 22-34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN3261 8/PG 3
- WGK Germany
- 3
β-Hydroxypyruvic acid Usage And Synthesis
Chemical Properties
White crystalline powder. Boiling point 257°C. Soluble in water (50g/L, 20°C) and white oil (<100g/kg, 20°C).
Occurrence
Reported found in blue cheese, provolone cheese, beer and cocoa
Uses
β-Hydroxypyruvic Acid is a metabolite involved in the pathway of carbon in photorespiration. It can also be used to treat fiber.
Definition
ChEBI: A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.
Biochem/physiol Actions
Metabolite involved in the pathway of carbon in photorespiration.
in vivo
Hydroxypyruvic acid (intravenous injection; 100 mg/ml; slowly over 10 min) increases the 5-h urinary oxalate and glycolate excretion to 0.68% (6.56 μmol) and 0.53% (5.10 μmol) in control rats, in addition, it increases to 2.43% (23.36 μmol) and 0.79% (7.59 μmol) of the dose in the vitamin-B6-deficient rats[1].
| Animal Model: | SD rat[1] |
| Dosage: | 100 mg/ml; slowly over 10 min |
| Administration: | Intravenous injection |
| Result: | Led to a significant increase of urinary oxalate and glycolate excretion in both control and vitamin-B6-deficient rats, but these changes are exaggerated in the vitamin-B6-deficient group. |
IC 50
Human Endogenous Metabolite
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