YM-53601
YM-53601 Basic information
- Product Name:
- YM-53601
- Synonyms:
-
- 2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride
- 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride
- YM-53601 Exclusive
- 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
- (E)-2-(2-Fluoro-2-(quinuclidin-3-ylidene)ethoxy)-9H-carbazole hydrochloride
- YM-53601 hydrochloride
- CAS:
- 182959-33-7
- MF:
- C21H21FN2O.ClH
- MW:
- 372.869
- Mol File:
- 182959-33-7.mol
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YM-53601 Chemical Properties
- Melting point:
- 236.5-237.2 °C
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- color
- Off-white to light brown
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Safety Information
- Safety Statements
- 22-24/25
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YM-53601 Usage And Synthesis
Uses
YM-53601 is a squalene synthetase inhibitor.
Definition
ChEBI: YM-53601 is a member of carbazoles.
Biological Activity
Squalene synthase inhibitor.
YM-53601 is a cell penetrant and potent squalene synthase inhibitor inhibits cholesterol biosynthesis in rodents. YM-53601 lowers cholesterol levels and triglyceride levels better than HMG-CoA reductase inhibitor (prevastatin) and fibrate (fenofibrate.).
in vivo
YM-53601 suppresses cholesterol biosynthesis in rats (ED50, 32?mg/kg)[1].
YM-53601 also reduces plasma non-HDL cholesterol levels in hamsters by approximately 70% at an oral dose of 50 mg/kg/day for 5 days[2].
YM-53601 potentiates Doxorubicin-mediated hepatocellular carcinoma cells (HCC) growth arrest and cell death in vivo[4].
| Animal Model: | Sprague-Dawley (SD) rats weighing 150-170?g[1] |
| Dosage: | 6.25, 12.5, 25 or 50?mg/kg |
| Administration: | Given a single p.o. |
| Result: | Inhibited cholesterol biosynthesis from acetate in a dose-dependent manner in rats. The ED50?value for YM-53601 cholesterol biosynthesis inhibition is 32? mg/kg. |
| Animal Model: | Five- to six-week-old male BALB/c athymic (nu/nu) nude mice[4] |
| Dosage: | 15 mg/kg |
| Administration: | 2 wk of daily treatment by p.o. gavage |
| Result: | Significantly decreased the intratumor cholesterol levels. |
YM-53601Supplier
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
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