Cefquinome sulfate Chemical Properties

Melting point:

161-166°C

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1/C23H24N6O5S2.H2O4S/c1-34-27-16(14-11-36-23(24)25-14)19(30)26-17-20(31)29-18(22(32)33)13(10-35-21(17)29)9-28-8-4-6-12-5-2-3-7-15(12)28;1-5(2,3)4/h4,6,8,11,17,21H,2-3,5,7,9-10H2,1H3,(H3-,24,25,26,30,32,33);(H2,1,2,3,4)/b27-16-;/t17-,21-;/s3

InChIKey

KYOHRXSGUROPGY-NIZYHBPXNA-N

SMILES

S(O)([O-])(=O)=O.C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3=CSC(N)=N3)=N\OC)C(=O)N12)C[N+]1=CC=CC2CCCCC1=2)(=O)O |&1:10,12,r|

Cefquinome sulfate Usage And Synthesis

Definition

NCIt: Cefquinome Sulfate is the sulfate form of cefquinome, a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity. Cefquinome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Description

Cefquinome sulfate is a veterinary, parenteral, fourth-generation cephalosporin belonging to the class of aminothiazolyl compounds. They have high cell permeability and high stability to beta-lactamases. They have broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria (e.g. Pseudomonas aeruginosa and Enterobacteriaceae).

Chemical Properties

Cefquinome sulfate is Off-White Solid

Uses

Cefquinome sulfate is an antibacterial used in veterinary medicine. Used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae. Also used to trea t mastitis in dairy cows.

Uses

An antibacterial used in veterinary medicine. Used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae. Also used to treat mastitis in dairy cows.

Mechanism of action

Cefquinome sulfate acts by inhibition of the cell wall synthesis, but it has a relatively short half-life of about 2.5 hours. It is less than 5% protein bound and is excreted unchanged in the urine.

Cefquinome sulfate(118443-89-3)Related Product Information

• 2,2'-Dithiobis(benzothiazole)
• MTT
• Fosthiazate
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Benzothiazole
• 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium inner salt
• Dimethyl sulfate
• Magnesium sulfate heptahydrate
• Ammonium sulfate
• Sodium sulfate
• Cefoselis sulfate
• Cefpirome sulfate
• 2-Methyl-4-isothiazolin-3-one
• Barium sulfate
• Aluminum sulfate
• sulfate
• 5,6,7,8-Tetrahydroquinoline
• Cefquinome sulfate