Beta-mangostin Chemical Properties

Melting point:

175-176℃

Boiling point:

616.5±55.0 °C(Predicted)

Density 

1.212

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

7.05±0.20(Predicted)

color 

Yellow

Stability:

Light Sensitive

Beta-mangostin Usage And Synthesis

Description

β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC₅₀ = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml). β-Mangostin inhibits fatty acid synthase (FASN) with an IC₅₀ value of 24.83 μM. It induces cell cycle arrest at the G₂/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E₂ (PGE₂; ) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.

Uses

β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC.

Definition

ChEBI: Beta-Mangostin is a member of xanthones.

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