Beta-mangostin Chemical Properties

Melting point:

175-176℃

Boiling point:

616.5±55.0 °C(Predicted)

Density 

1.212

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

7.05±0.20(Predicted)

color 

Yellow

Stability:

Light Sensitive

Beta-mangostin Usage And Synthesis

Description

β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC₅₀ = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml). β-Mangostin inhibits fatty acid synthase (FASN) with an IC₅₀ value of 24.83 μM. It induces cell cycle arrest at the G₂/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E₂ (PGE₂; ) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.

Uses

β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC.

Definition

ChEBI: Beta-Mangostin is a member of xanthones.

IC 50

Plasmodium

References

[1] MUNEKAZU IINUMA. Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin-resistant Staphylococcus aureus[J]. Journal of Pharmacy and Pharmacology, 1996, 48 8: 861-865. DOI: 10.1111/j.2042-7158.1996.tb03988.x
[2] K LIKHITWITAYAWUID  J K  T Phadungcharoen. Antimalarial xanthones from Garcinia cowa.[J]. Planta medica, 1998, 64 1: 70-72. DOI: 10.1055/s-2006-957370
[3] SUNIT SUKSAMRARN. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.[J]. Chemical & pharmaceutical bulletin, 2003, 51 7: 857-859. DOI: 10.1248/cpb.51.857
[4] HE ZHONG JIANG . Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 20: Pages 6045-6047. DOI: 10.1016/j.bmcl.2010.08.061
[5] SUVITHA SYAM . β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells[J]. Journal of Functional Foods, 2014, 6: Pages 290-304. DOI: 10.1016/j.jff.2013.10.018
[6] SUVITHA SYAM . β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo[J]. Journal of ethnopharmacology, 2014, 153 2: Pages 435-445. DOI: 10.1016/j.jep.2014.02.051

Beta-mangostin(20931-37-7)Related Product Information

• Gamma-mangostin
• Mangostin
• 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE
• 2,4,4'-TRIHYDROXYBENZOPHENONE
• 2-HYDROXY-5-METHYLBENZOPHENONE
• 2,3',4,4',6-Pentahydroxybenzophenone
• 4,4'-Dihydroxybenzophenone
• 2,2',4,4'-Tetrahydroxybenzophenone
• GENTISIN
• 2,3',4,4'-TETRAHYDROXYBENZOPHENONE
• 2,2'-Dihydroxy-4-methoxybenzophenone
• PHLOROBENZOPHENONE
• 1,3-dihydroxyxanthone
• 2-HYDROXY-4,6-DIMETHOXY-3-METHYLACETOPHENONE
• GENTISEIN
• 2-ETHYL-4'-METHOXYBENZOPHENONE
• isogentisin
• Beta-mangostin