Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Chemical Properties

Melting point:

305℃

Boiling point:

346.2±34.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.95±0.20(Predicted)

Appearance

Light brown to gray Solid

Safety Information

HS Code 

2933998090

Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) Usage And Synthesis

Synthesis

3-Aminoisonicotinic acid (691 mg, 5.0 mmol), formamidine acetate (573 mg, 5.5 mmol) and anhydrous ethanol (10 mL) were added to a Biotage microwave reactor tube. The reaction mixture was placed in a microwave reactor and heated at 160 °C for 30 min. After completion of the reaction, the reaction solution was diluted with deionized water (20 mL) and cooled to 0 °C in an ice bath. The resulting suspension was extracted and the filter cake was washed with ice-cooled deionized water (10 mL) to afford quinazoline A2 (259 mg, 35% yield) in white solid form. The product was analyzed by LC-MS showing purity >98% (m/z = 148.0 [M + H]+, retention time Rt = 0.604 min).

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[2] Patent: WO2014/179237, 2014, A1. Location in patent: Paragraph 00491

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