(S)-2-Amino-2-(3-fluorophenyl)ethanol Chemical Properties

Melting point:

101-103 °C

Boiling point:

286.3±25.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

12.40±0.10(Predicted)

Safety Information

HS Code 

2922190090

(S)-2-Amino-2-(3-fluorophenyl)ethanol Usage And Synthesis

Uses

Used as an intermediate in laboratory research.

Preparation

(Rs,2S)-N-((tert-butyldimethylsilyloxy)-1-(4-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (0.280 g, 0.749 mmol) was dissolved in MeOH (10 mL) and then HCl/MeOH (4 M, 2.0 mL) was added. The solution was stirred at room temperature for 3 h. After that, the solvent was removed under vacuum and the residue neutralized with saturated NaHCO₃ (20 mL). The mixture was extracted with CH₂Cl₂/MeOH and the organic phases dried (Na2SO4) and concentrated to obtained (S)-2-Amino-2-(3-fluorophenyl)ethanol.

Reactions

By coupling an amine group to a carboxyl group, (S)-2-Amino-2-(3-fluorophenyl)ethanol could be employed to synthesize (S)-N-{1-(3-fluorophenyl)-2-hydroxyethyl}-4-{5-methyl-2-(phenylamino)pyrimidin-4-yl}-1H-pyrrole-2-carboxamide..

Synthesis

(S)-2-Amino-2-(3-fluorophenyl)ethanol can be prepared by the amination reaction of 1-Ethenyl-3-fluorobenzene and ammonia water.

(S)-2-Amino-2-(3-fluorophenyl)ethanol(325152-98-5)Related Product Information

• Ethanol