3,3'-Dithiobis(sulfosuccinimidylpropionate) Chemical Properties

Density 

1.94

storage temp. 

2-8°C

pka

-0.34±0.20(Predicted)

form 

solid

color 

Light tan

Safety Information

Safety Statements 

26-36

HS Code 

29309090

3,3'-Dithiobis(sulfosuccinimidylpropionate) Usage And Synthesis

Chemical Properties

12.0

Uses

It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent.

Uses

sulfhydryl reactive cleavable heterobifunctional cross-linking reagent, pyridine-2-thione release can be monitored at 343 nm after reactions with sulfhydryl groups

General Description

DTSSP is 3,3′-Dithiobis(sulfosuccinimidylpropionate), which contains an amine-reactive N-hydroxysulfosuccinimide (sulfo-NHS) ester at each end of an 8-carbon spacer arm. Sulfo-NHS esters react with primary amines at pH 7-9 to form stable amide bonds, along with release of the N-hydroxysulfosuccinimide leaving group. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for sulfo-NHS-ester crosslinking reagents. DSS, the non-sulfonated analog of DTSSP is also available for applications that require a membrane-permeable crosslinker.

3,3'-Dithiobis(sulfosuccinimidylpropionate)(81069-02-5)Related Product Information

• SODIUM ISOSTEAROYL-2-LACTYLATE
• 3,3'-DITHIODIPROPIONIC ACID
• 3,3'-Dithiobis(sulfosuccinimidylpropionate)
• 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)