3-BROMO-4-CHLOROANILINE Chemical Properties

Melting point:

82°C

Boiling point:

290.6±20.0℃ (760 Torr)

Density 

1.722±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

129.5±21.8℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

2.89±0.10(Predicted)

color 

White to Brown

Safety Information

Risk Statements 

20/21/22-33

Safety Statements 

36/37

RIDADR 

2811

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29214200

3-BROMO-4-CHLOROANILINE Usage And Synthesis

Description

3-Bromo-4-chloroaniline can be used as an intermediate in pharmaceutical synthesis, such as the preparation of Vismodegib, the trade name is Erivedge, the chemical name is 2-chloro-N-(4-chloro-3 -(Pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, developed by Curis, Genentech and Evotec in cooperation, was approved by the U.S. Food and Drug Administration (FDA) on January 30, 2012 ) marketing approval as a small molecule targeted inhibitor of the Hedgehog pathway for the treatment of basal cell carcinoma.

Uses

3-Bromo-4-chloroaniline is an amine derivative and can be used as an organic reagent.

Synthesis

Dissolve p-chloronitrobenzene in sulfuric acid aqueous solution, slowly add bromine reagent (bromine or potassium bromate), and react to obtain 3-bromo-4-chloroaniline.

References

[1] Patent: WO2005/103010, 2005, A2. Location in patent: Page/Page column 37-38
[2] Patent: WO2014/74422, 2014, A1. Location in patent: Paragraph 00183
[3] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984, vol. 38, # 10, p. 877 - 884
[5] American Chemical Journal, 1899, vol. 22, p. 247

3-BROMO-4-CHLOROANILINE(823-54-1)Related Product Information

• (N,N-Bis-t-Boc)-5-bromo-2-chloroaniline
• 2-Bromo-5-chloroaniline 97%,2-BROMO-5-CHLOROANILINE
• Halofuginone Lactate
• 2-BROMO-3-CHLORO-6-AMINO BENZOIC ACID
• Halofuginone hydrobromide
• 2-Amino-4-bromo-5-chlorobenzoic acid
• 1-Bromo-2-chloro-4-methoxy-5-nitrobenzene
• Halofuginone
• 7-Bromo-6-chloro-4-quinazolinone
• 2-Bromo-4-chloroaniline,98%,2-BROMO-4-CHLOROANILINE,DISCONTINUED !2-Bromo-4-chloroaniline,2-Bromo-4-chloroaniline 99%
• 3-bromo-2-chloroaniline
• 3-Bromo-5-chloroaniline
• 3-BROMO-6-CHLOROANILINE,5-BROMO-2-CHLOROANILINE
• 4-BROMO-3-CHLOROANILINE PESTANAL, 250 MG,4-BROMO-3-CHLOROANILINE,4-BROMO-3-CHLOROANILINE 98+%
• 4-Bromo-2-chloroaniline 98%,4-BROMO-2-CHLOROANILINE,4-BROMO-2-CHLOROANILINE, 98+%
• 3-BROMO-4-CHLOROANILINE
• 1-BROMO-2-CHLORO-4-METHYL-5-NITRO-BENZENE
• 3-BROMO-4-CHLORONITROBENZENE