3-BROMO-4-CHLOROANILINE Chemical Properties

Melting point:

82°C

Boiling point:

290.6±20.0℃ (760 Torr)

Density 

1.722±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

129.5±21.8℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

2.89±0.10(Predicted)

color 

White to Brown

Safety Information

Risk Statements 

20/21/22-33

Safety Statements 

36/37

RIDADR 

2811

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29214200

3-BROMO-4-CHLOROANILINE Usage And Synthesis

Description

3-Bromo-4-chloroaniline can be used as an intermediate in pharmaceutical synthesis, such as the preparation of Vismodegib, the trade name is Erivedge, the chemical name is 2-chloro-N-(4-chloro-3 -(Pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, developed by Curis, Genentech and Evotec in cooperation, was approved by the U.S. Food and Drug Administration (FDA) on January 30, 2012 ) marketing approval as a small molecule targeted inhibitor of the Hedgehog pathway for the treatment of basal cell carcinoma.

Uses

3-Bromo-4-chloroaniline is an amine derivative and can be used as an organic reagent.

Synthesis

Dissolve p-chloronitrobenzene in sulfuric acid aqueous solution, slowly add bromine reagent (bromine or potassium bromate), and react to obtain 3-bromo-4-chloroaniline.

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