5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Chemical Properties

Melting point:

117 °C (decomp)

Boiling point:

489.0±45.0 °C(Predicted)

Density 

1.462±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Solid

pka

4.50±1.00(Predicted)

color 

White to Off-White

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Usage And Synthesis

Chemical Properties

White to Off-white Solid.

Uses

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).

Application

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene] is an intermediate for the synthesis of sitagliptin. Sitagliptin is a new type of anti-type II diabetes drug approved by the FDA and the first dipeptidyl peptidase-IV inhibitor drug for the treatment of type II diabetes.

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione(764667-64-3)Related Product Information

• Sitagliptin Impurity 28
• Sitagliptin Impurity 46
• Sitagliptin Impurity 77
• Sitagliptin impurity 5
• Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
• ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
• 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
• Sitagliptin Impurity 34
• 2,4,5-TRIFLUOROBENZYL CHLORIDE
• (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
• Sitagliptin
• Sitagliptin Impurity 14
• Sitagliptin Defuoro IMpurity 5
• Sitagliptin DeaMino IMpurity 1
• (S)-Sitagliptin Phosphate
• 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
• (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione