Ethoxysanguinarine CAS#: 28342-31-6

Ethoxysanguinarine Basic information

Product Name:

Ethoxysanguinarine

Synonyms:

Ethoxysanguinarine
($$+/-$$)-Sanguinarine pseudoethanolate
14-Ethoxy-13,14-dihydrosanguinarine
14-Ethoxy-13-Methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine
14-Ethoxy-13,14-dihydrosanguinarine (±)-Sanguinarine pseudoethanolate
6-Ethoxysanguinarine
6-Ethoxydihydrosanguinarine
Ethoxysanguinarine Stemonine

CAS:

28342-31-6

MF:

C22H19NO5

MW:

377.39

Product Categories:

reagent
standard substance

Mol File:

28342-31-6.mol

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Ethoxysanguinarine Chemical Properties

Melting point:: 210-212℃ (ethanol )
Boiling point:: 563.7±50.0 °C(Predicted)
Density: 1.45±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
pka: 0.59±0.40(Predicted)
form: Solid
color: White to yellow
InChI: InChI=1S/C22H19NO5/c1-3-24-22-19-13(6-7-16-21(19)28-11-25-16)14-5-4-12-8-17-18(27-10-26-17)9-15(12)20(14)23(22)2/h4-9,22H,3,10-11H2,1-2H3
InChIKey: FCEXWTOTHXCQCQ-UHFFFAOYSA-N
SMILES: C1=C2C(N(C)C(OCC)C3=C2C=CC2OCOC3=2)=C2C=C3OCOC3=CC2=C1

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Ethoxysanguinarine Usage And Synthesis

Uses

Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1].

in vivo

Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice^[1].

Animal Model:	Nude immunodeficient mice (5-week-old, weighing about 16 g)^[1]
Dosage:	0.5 mg/kg
Administration:	Subcutaneous injection; 5 times per week for 4 weeks
Result:	Exhibited antitumor effects without reduce the body weight of the mice.

References

[1] Jin L, et al. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. Int J Oncol. 2018 Mar 16. DOI:10.3892/ijo.2018.4323

EthoxysanguinarineSupplier

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