2-Biphenylcarboxylic acid Chemical Properties

Melting point:

111-113 °C(lit.)

Boiling point:

199 °C10 mm Hg(lit.)

Density 

1.1184 (rough estimate)

refractive index 

1.5954 (estimate)

Flash point:

343-344°C

storage temp. 

Sealed in dry,Room Temperature

form 

Crystalline Powder

pka

3.46(at 25℃)

color 

White to beige

Water Solubility 

insoluble

BRN 

974075

InChIKey

ILYSAKHOYBPSPC-UHFFFAOYSA-N

CAS DataBase Reference

947-84-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Biphenylcarboxylic acid(947-84-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39-37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29163900

MSDS

• Language:English Provider:2-Phenylbenzoic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Biphenylcarboxylic acid Usage And Synthesis

Chemical Properties

2-Biphenylcarboxylic acid is White powder

Uses

2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists.

Uses

It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product.

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015

Purification Methods

Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.]

2-Biphenylcarboxylic acid(947-84-2)Related Product Information

• BIPHENYL-3-CARBONYL CHLORIDE
• Salicylic acid
• 2-Benzoylbenzoic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Benzoic acid
• Methyl 2-bromobenzoate
• 2-Iodobenzoic acid
• Folic acid
• Glycine
• 2,3,4-Trihydroxybenzoic acid
• Thiosalicylic acid
• 2-Nitrobenzoic acid
• 1-PHENYL-2-PROPANOL
• 1-Phenyl-2-nitropropene
• 2,4-Dichlorobenzoic acid
• 2-Phenylphenol
• 2-Fluorobenzaldehyde
• 2-Fluorobenzoyl chloride