L-Azidohomoalanine
L-Azidohomoalanine Basic information
- Product Name:
- L-Azidohomoalanine
- Synonyms:
-
- 2(S)-Amino-4-azido-butanoic Acid
- (2S)-2-Amino-4-azido-butanoic Acid
- (S)-2-Amino-4-azidobutanoic acid
- Ccris 3366
- AzidohoMoanaline (AHA)
- 4-Azido-hoMoalanine
- H-Dab(N2)-OH, L-g-azidohoMoalanine, H-g-Aha-OH
- H-g-azido-Abu-OH
- CAS:
- 120042-14-0
- MF:
- C4H8N4O2
- MW:
- 144.13
- Product Categories:
-
- Amino Acids 13C, 2H, 15N
- Amino Acids & Derivatives
- Mol File:
- 120042-14-0.mol
L-Azidohomoalanine Chemical Properties
- Melting point:
- 220-2230C
- storage temp.
- -20°C Freezer
- solubility
- Water
- form
- Solid
- color
- Off-White
L-Azidohomoalanine Usage And Synthesis
Description
L-azidohomoalaine provides a fast, sensitive, non-toxic and non-radioactive alternative to the traditional radioactive technique, 35S-methionine for the detection of nascent protein. L-azidohomoalaine is an amino acid analog that contains a small modification and its azido moiety can be fed to cultured cells and incorporated into proteins during active protein synthesis.
Chemical Properties
Off-White Solid
Uses
2(S)-Amino-4-azido-butanoic Acid is a novel mutagenic amino acid.
Synthesis
A concise and highly efficient synthetic route to l-azidohomoalanine (l-Aha) and its homologues is presented here. Starting from inexpensive N-Boc-O-Bn-l-aspartic acid, gram quantities of l-Aha hydrochloride can be prepared with high purity. The reactions can be completed within 1 week and the products can be incorporated into proteins using l-methionine auxotrophs.
IC 50
Alkyl-Chain
References
[1] STEFANIE ROTH Neil R T William C Drewe. A concise and scalable route to L-azidohomoalanine[J]. Nature Protocols, 2010, 5 12: 1967-1973. DOI:10.1038/nprot.2010.164.
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