O-Desmorpholinopropyl Gefitinib Chemical Properties

Melting point:

>260°C (dec.)

Boiling point:

478.8±45.0 °C(Predicted)

Density 

1.489±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Very Slightly, Heated)

form 

Solid

pka

8.18±0.40(Predicted)

color 

Pale Beige to Beige

Safety Information

HS Code 

2933.59.8000

O-Desmorpholinopropyl Gefitinib Usage And Synthesis

Description

O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, a potent inhibitor of tyrosine phosporylation in EGFR. The chemical structure of O-Desmorpholinopropyl Gefitinib consists of a quinazoline-6-ol core with a phenylamino group attached to a chloro-fluoro-phenyl ring, enabling it to interact with multiple biological targets. It is involved in inhibiting enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).

Chemical Properties

Tan Solid

Uses

A metabolite of Gefitinib.

Definition

ChEBI: O-Desmorpholinopropyl Gefitinib is a member of quinazolines.

O-Desmorpholinopropyl Gefitinib(184475-71-6)Related Product Information

• Gefitinib Impurity 11
• Gefitinib-d6
• 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
• 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
• 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
• 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
• 4-(3-Chloropropyl)morpholine
• 3-Chloro-4-fluoroaniline
• 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
• (Trifluoromethoxy)benzene
• Sulfaquinoxaline
• 4-Methoxyphenol
• Anisole
• Quinoxaline
• Gefitinib Chloro Impurity
• Gefitinib Impurity 8
• 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
• Gefitinib 3,4-Difluoro Impurity HCl