Curdione Chemical Properties

Melting point:

61.5-62.0 °C

Boiling point:

318.82°C (rough estimate)

Density 

0.93

refractive index 

1.4700 (estimate)

Flash point:

130℃

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

form 

Cryst.

LogP

3.120 (est)

NIST Chemistry Reference

6,10-Dimethyl-3-(1-methylethyl)-6-cyclodecene-1,4-dione(13657-68-6)

Safety Information

HS Code 

29143990

Curdione Usage And Synthesis

Chemical Properties

Colorless prismatic crystal (anhydrous ethanol), melting point 61～62℃, [α]25D+26°(c=1, chloroform), easily soluble in ether and chloroform, slightly soluble in petroleum ether.

Uses

Curdione can be used for content determination, identification and pharmacological experiments, etc. Pharmacological and pharmacological effects: It has obvious inhibitory effect on mouse sarcoma 37, mouse cervical cancer U14 and mouse Ehrlich ascites cancer, and can make cancer cells cross necrosis. Ehrlich ascites carcinoma treated with this product can successfully obtain active immunity in mice. It has good curative effect in clinical treatment of cervical cancer.

Definition

ChEBI: Curdione is a germacrane sesquiterpenoid.

Biological Activity

Curdione is a sesquiterpenoid substance isolated from Curcuma zedoary, with high biological activity, which has the effect of inhibiting platelet aggregation and resisting thrombosis.

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