Mitonafide
Mitonafide Basic information
- Product Name:
- Mitonafide
- Synonyms:
-
- 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione
- 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
- M-4212【pharmaceutical】
- 1H-Benz[de]isoquinoline-1,3 (2H)-dione, 2-[2-(dimethylamino)ethyl]-5-nitro-
- Aids070527
- Aids-070527
- N-(2-(Dimethylamino)ethyl)-3-nitronaphthalimide
- Nsc300288
- CAS:
- 54824-17-8
- MF:
- C16H15N3O4
- MW:
- 313.31
- Product Categories:
-
- Amines
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 54824-17-8.mol
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Mitonafide Chemical Properties
- Melting point:
- 138-139 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 496.8±30.0 °C(Predicted)
- Density
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.76±0.28(Predicted)
- color
- Brown
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Mitonafide Usage And Synthesis
Uses
A Naphthalimides with potent anticancer activity.
in vivo
Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice[4].
Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model[6].
Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg[5].
| Animal Model: | S-180 bearing mice[4] |
| Dosage: | 0.5 mg/kg and 1 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) for 1-7 days |
| Result: | Increased in median survival times. |
| Animal Model: | HepG2 xenograft model [6] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), twice a day. |
| Result: | Exhibited a relative tumor increment rates (T/C) value of 28.8%. |
MitonafideSupplier
J & K SCIENTIFIC LTD.
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- 18210857532
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LGM Pharma
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Chemsky（shanghai）International Co.,Ltd.
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- 021-50135380
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Synchem OHG
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- +49 5662 408730
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Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com