Pramlintide
Pramlintide Basic information
- Product Name:
- Pramlintide
- Synonyms:
-
- Triproamylin
- Lys-c[Cys-Asn-Thr-Ala-Thr-Cys]-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu -Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly -Ser-Asn-Thr-Tyr-NH2
- CL062
- Pramlintide D10
- PramlintideQ: What is Pramlintide Q: What is the CAS Number of Pramlintide Q: What is the storage condition of Pramlintide Q: What are the applications of Pramlintide
- Pramlintide
- Pramlintide Triproamylin
- CAS:
- 151126-32-8
- MF:
- C171H267N51O53S2.C2H4O2.H2O
- MW:
- 4027.49
- EINECS:
- 1592732-453-0
- Mol File:
- 151126-32-8.mol
Pramlintide Chemical Properties
- solubility
- soluble in Water
- form
- Solid
- color
- White
- Water Solubility
- Soluble to 1 mg/ml in water
Pramlintide Usage And Synthesis
Uses
Antidiabetic.
Enzyme inhibitor
This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a role in glycemic regulation by retarding gastric emptying and promoting satiety. Amylin helps to prevent post-prandial spikes in blood glucose. Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8; Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2; Tradename: Symlin?) contains three prolyl residues that are found in Rat Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG SNTY) and is nonamyloidogenic.)
storage
Store at -20°C
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