Pramlintide Chemical Properties

solubility 

soluble in Water

form 

Solid

color 

White

Water Solubility 

Soluble to 1 mg/ml in water

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge:Cys2-Cys7)

InChIKey

FVNLNEGMCMHEBF-CLRARMPYNA-N

Pramlintide Usage And Synthesis

Uses

Antidiabetic.

Enzyme inhibitor

This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a role in glycemic regulation by retarding gastric emptying and promoting satiety. Amylin helps to prevent post-prandial spikes in blood glucose. Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8; Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2; Tradename: Symlin?) contains three prolyl residues that are found in Rat Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG SNTY) and is nonamyloidogenic.)

storage

Store at -20°C

Description

Pramlintide Synthetic is a single, non-glycosylated polypeptide chain containing 37 amino acids, having a molecular mass of 3949.4 Dalton and a Molecular formula of C₁₇₁H₂₆₇N₅₁O₅₃S₂.

Background

Pramlintide acetate is a hormone that is released into the bloodstream, in a similar pattern as insulin. Pramlintide aids in the absorption of glucose by slowing gastric emptying, promoting satiety, and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin.

Pramlintide(151126-32-8)Related Product Information

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