Romifidine
Romifidine Basic information
- Product Name:
- Romifidine
- Synonyms:
-
- 2-(2-Bromo-6-fluoroanilino)-2-imidazoline
- Romidys
- St 2130
- STH 2130
- Romifidine
- N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
- Romifidine >
- 1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-
- CAS:
- 65896-16-4
- MF:
- C9H9BrFN3
- MW:
- 258.09
- EINECS:
- 202-303-5
- Mol File:
- 65896-16-4.mol
Romifidine Chemical Properties
- Melting point:
- 110 °C
- Boiling point:
- 303.2±52.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (968.65 mM; Need ultrasonic)
- pka
- 8.69±0.50(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
Romifidine Usage And Synthesis
Uses
Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].
in vivo
Romifidine (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1]. Romifidine (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].
References
[1] England GC, et al. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194-201. DOI:10.1111/j.1365-2885.1992.tb01007.x
[2] Hamm D, et al. Sedative and analgesic effects of detomidine and romifidine in horses. Vet Rec. 1995 Apr 1;136(13):324-7. DOI:10.1136/vr.136.13.324
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