Traxanox
Traxanox Basic information
- Product Name:
- Traxanox
- Synonyms:
-
- Traxanox
- 5H-[1]Benzopyrano[2,3-b]pyridin-5-one, 9-chloro-7-(2H-tetrazol-5-yl)-
- CAS:
- 58712-69-9
- MF:
- C13H6ClN5O2
- MW:
- 299.67
- Mol File:
- 58712-69-9.mol
Traxanox Chemical Properties
- Melting point:
- >300°
Traxanox Usage And Synthesis
Uses
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.
Definition
ChEBI: Traxanox is a pyridochromene.
References
[1] [Effect of traxanox sodium on inflammatory response] DOI:10.1254/fpj.86.329
[2] Goto K, et al. Inhibitory effect of traxanox sodium on IgE-mediated histamine release from passively-sensitized mast cells of the rat in vitro. Int Arch Allergy Appl Immunol. 1982;68(4):332-337. DOI:10.1159/000233122
[3] Ikegami K, et al. The effects of traxanox sodium of cyclic AMP phosphodiesterase and the concentration of cyclic AMP in the plasma of rats. Chem Pharm Bull (Tokyo). 1983 Feb;31(2):752-5. DOI:10.1248/cpb.31.752