5-Aziridino-2,4-dinitrobenzamide Chemical Properties

Melting point:

173 °C

Boiling point:

427.2±45.0 °C(Predicted)

Density 

1.671±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

solid

pka

14.23±0.50(Predicted)

color 

Yellow to Dark Yellow

InChIKey

WOCXQMCIOTUMJV-UHFFFAOYSA-N

Safety Information

WGK Germany 

3

HS Code 

2933.99.7500

5-Aziridino-2,4-dinitrobenzamide Usage And Synthesis

Description

CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.

Uses

5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.

Uses

Tretazicar is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.

Biochem/physiol Actions

CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.

in vivo

References

[1] R J KNOX. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.[J]. Cancer research, 2000, 60 15: 4179-4186.

5-Aziridino-2,4-dinitrobenzamide(21919-05-1)Related Product Information

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