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Tenidap

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Tenidap Basic information

Product Name:
Tenidap
Synonyms:
  • TENIDAP
  • AKOS 91367
  • 5-Chloro-2,3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide
  • CP66248,CP-66248-2
  • (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide
  • (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide
  • 1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-
  • TENIDAP USP/EP/BP
CAS:
120210-48-2
MF:
C14H9ClN2O3S
MW:
320.75
Mol File:
120210-48-2.mol
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Tenidap Chemical Properties

Melting point:
230° (dec)
Boiling point:
538.1±60.0 °C(Predicted)
Density 
1.648±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
form 
powder
pka
4.50±1.00(Predicted)
color 
faint yellow to dark yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Tenidap Usage And Synthesis

Uses

Anti-inflammatory (osteoarthritis and rheumatoid arthritis).

Uses

Tenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Definition

ChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

Biological Activity

NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).

storage

Store at +4°C

Mode of action

Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1).

TenidapSupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
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