norisoboldine
norisoboldine Basic information
- Product Name:
- norisoboldine
- Synonyms:
-
- norisoboldine
- (+)-Laurelliptine
- (+)-N-Norisoboldine
- (6aS)-5,6,6a,7-Tetrahydro-2,10-dimethoxy-4H-dibenzo[de,g]quinoline-1,9-diol
- (S)-(+)-Laurelliptine
- Norisoboldine, 98%, from Lindera aggregata (Sims) Kosterm.
- 4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-, (6aS)-
- (+)-Norisoboldine
- CAS:
- 23599-69-1
- MF:
- C18H19NO4
- MW:
- 313.35
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 23599-69-1.mol
More
Less
norisoboldine Chemical Properties
- Melting point:
- 89-191℃
- Boiling point:
- 553.0±50.0 °C(Predicted)
- Density
- 1.313
- solubility
- ≥ 31.3mg/mL in DMSO
- pka
- 9.58±0.20(Predicted)
- form
- Powder
- color
- Brown to khaki
- InChI
- InChI=1S/C18H19NO4/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1
- InChIKey
- HORZNQYQXBFWNZ-LBPRGKRZSA-N
- SMILES
- N1[C@]2([H])C3=C(C(O)=C(OC)C=C3CC1)C1=CC(OC)=C(O)C=C1C2
More
Less
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29339900
More
Less
norisoboldine Usage And Synthesis
Chemical Properties
Brown crystalline powder, soluble in methanol, derived from Linderae odorata.
Uses
(+)-Norisoboldine is an anti-arthritis alkaloid isolated from radix linderae which has been shown to attenuate osteoclast differentiation and inflammatory bone erosion in aryl hydrocarbon receptor-dependant manner.
in vivo
Norisoboldine (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment[1].
Norisoboldine (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons[2].
| Animal Model: | Male ICR mice (18–22 g) |
| Dosage: | 10~40 mg/kg |
| Administration: | P.o. |
| Result: | Significantly reduced the severity of joint swelling and erythema during the course of the experiment. |
| Animal Model: | Female C57BL/6 mice (18–22 g) |
| Dosage: | 40 mg/kg |
| Administration: | I.g. |
| Result: | Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons. |
norisoboldineSupplier
Chengdu Nakeli Biotechnology Co., Ltd. Gold
- Tel
- 028-61983833 19138982515
- 3265827856@qq.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Sichuan Kulinan Technology Co., Ltd
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
Shenzhen Sungening Bio-Tech Co., Ltd
- Tel
- +86-0755-89668383
- sales@sungening.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
More
Less
norisoboldine(23599-69-1)Related Product Information
- LINDERANE
- Laetanine
- Boldine
- LAUROLITSINE
- HigenaMine Hydrochloride
- Linderene acetate
- (R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one
- Demethyl-Coclaurine
- Lindeneol
- norisoboldine
- BOLDINE DIMETHYL ETHER
- laurotetanine
- Thalicarpine
- L-DICENTRINE
- AKOS 208-03
- 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6 -methyl-, (S)-