1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Chemical Properties

solubility 

DMF: >125 μg/ml; DMSO: <20 μg/ml; Ethanol: >10 mg/ml; PBS pH 7.2: >11 mg/ml

form 

A lyophilized powder

1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE Usage And Synthesis

Description

2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP. 2-O-ethyl PAF C-16 causes aggregation of neutrophils in the presence of divalent cations and a desensitization to aggregation in the absence of divalent cations.

Uses

2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM[1].

Definition

ChEBI: 2-O-ethyl PAF C-16 is a glycerophosphocholine and an ether lipid.

References

[1] Aoki Y, et al. A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DOI:10.1016/0022-1759(95)00147-3

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