NSC54180 Chemical Properties

Melting point:

205-208 °C

Boiling point:

359.2±42.0 °C(Predicted)

Density 

1.739±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.68±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2916399090

NSC54180 Usage And Synthesis

Synthesis

A) Synthesis of 5-bromo-2-hydroxy-4-methylbenzoic acid: 2-hydroxy-4-methylbenzoic acid (5.00 g) was dissolved in acetic acid (70.0 mL) and bromine (1.68 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 5.5 hours. Upon completion of the reaction, water was added to the mixture and the precipitate was collected by filtration. The precipitate was dried under reduced pressure to give the target compound 5-bromo-2-hydroxy-4-methylbenzoic acid (6.78 g). The result of mass spectrometry analysis: [M-H]? 229.0.

References

[1] Patent: WO2018/24224, 2018, A1. Location in patent: Page/Page column 80; 81
[2] Patent: US2018/127370, 2018, A1. Location in patent: Paragraph 0892
[3] Journal of the Chemical Society, 1914, vol. 105, p. 1891
[4] Journal fuer Praktische Chemie (Leipzig), 1915, vol. <2> 91, p. 388
[5] Patent: EP1391451, 2004, A1. Location in patent: Page 84

NSC54180(6623-35-4)Related Product Information

• NSC54180
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• 4-BROMO-1-HYDROXYANTHRAQUINONE-2-CARBOXYLIC ACID
• METHYL 5-BROMO-2-HYDROXY-4-METHYLBENZOATE