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IODIPAMIDE

Basic information Safety Supplier Related

IODIPAMIDE Basic information

Product Name:
IODIPAMIDE
Synonyms:
  • 3,3’-(adipoyldiimino)bis(2,4,6-triiodo-benzoicaci
  • adipiodon
  • 3,3(ADIPOYLDIIMINO)BIS(2,4,6-TRIIODOBENZOIC ACID)
  • 3,3'-ADIPOYLDIIMINOBIS(2,4,6-TRIIODOBENZOIC ACID)
  • 2,2,4,4,6,6-hexaiodo-3,3-adipoyldiiminodi(benzoic acid)
  • 3,3'-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodobenzoic Acid
  • Adipic Acid Bis(3-carboxy-2,4,6-triiodoanilide)
  • 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-keto-hexanoyl]amino]-2,4,6-triiodo-benzoic acid
CAS:
606-17-7
MF:
C20H14I6N2O6
MW:
1139.76
EINECS:
210-105-5
Product Categories:
  • Aromatics
  • Diagnostic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
606-17-7.mol
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IODIPAMIDE Chemical Properties

Melting point:
306-308°C (dec.)
Boiling point:
908.6±65.0 °C(Predicted)
Density 
2.5848 (estimate)
refractive index 
nD21.5 1.3294 (c = 0.445 in methanol)
storage temp. 
Room Temperature
solubility 
DMSO (Slightly), Methanol (Very Slightly)
form 
Solid
pka
pKa 3.5(H2O) (Uncertain)
color 
White
Water Solubility 
0.46g/L(20 ºC)
Merck 
5022
EPA Substance Registry System
Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo- (606-17-7)
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Safety Information

WGK Germany 
3
RTECS 
DG0949500
HS Code 
2924296000
Hazardous Substances Data
606-17-7(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg)

MSDS

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IODIPAMIDE Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Cholografin,Squibb,US,1954

Uses

Diagnostic aid (radiopaque medium-cholecystographic).

Uses

antihypertensive, diuretic, activates K channels and AMPA receptors

Definition

ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-).

Manufacturing Process

125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of chlorobenzene and 15 g of adipic acid dichloride are added at a temperature between 110° and 130°C drop by drop to the solution. After evolution of hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered hot with suction, washed with chlorobenzene, extracted by boiling with methanol and, for purification, dissolved in an amount of methanolic caustic soda solution required for neutralization, filtered with charcoal, and precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C (with decomposition).

brand name

Pharmaceutic necessity for Iodipamide Meglumine [Injection]. Cholografin (Bristol-Myers Squibb).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Hazard

Toxic by ingestion.

IODIPAMIDESupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
INTATRADE GmbH
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+49 3493/605464
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Energy Chemical
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021-021-58432009 400-005-6266
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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sj_scrc@sinopharm.com