IODIPAMIDE
IODIPAMIDE Basic information
- Product Name:
- IODIPAMIDE
- Synonyms:
-
- 3,3’-(adipoyldiimino)bis(2,4,6-triiodo-benzoicaci
- adipiodon
- 3,3(ADIPOYLDIIMINO)BIS(2,4,6-TRIIODOBENZOIC ACID)
- 3,3'-ADIPOYLDIIMINOBIS(2,4,6-TRIIODOBENZOIC ACID)
- 2,2,4,4,6,6-hexaiodo-3,3-adipoyldiiminodi(benzoic acid)
- 3,3'-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodobenzoic Acid
- Adipic Acid Bis(3-carboxy-2,4,6-triiodoanilide)
- 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-keto-hexanoyl]amino]-2,4,6-triiodo-benzoic acid
- CAS:
- 606-17-7
- MF:
- C20H14I6N2O6
- MW:
- 1139.76
- EINECS:
- 210-105-5
- Product Categories:
-
- Aromatics
- Diagnostic
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 606-17-7.mol
IODIPAMIDE Chemical Properties
- Melting point:
- 306-308°C (dec.)
- Boiling point:
- 908.6±65.0 °C(Predicted)
- Density
- 2.5848 (estimate)
- refractive index
- nD21.5 1.3294 (c = 0.445 in methanol)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- pKa 3.5(H2O) (Uncertain)
- color
- White
- Water Solubility
- 0.46g/L(20 ºC)
- Merck
- 5022
- EPA Substance Registry System
- Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo- (606-17-7)
Safety Information
- WGK Germany
- 3
- RTECS
- DG0949500
- HS Code
- 2924296000
- Hazardous Substances Data
- 606-17-7(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg)
MSDS
- Language:English Provider:SigmaAldrich
IODIPAMIDE Usage And Synthesis
Chemical Properties
Crystalline Solid
Originator
Cholografin,Squibb,US,1954
Uses
Diagnostic aid (radiopaque medium-cholecystographic).
Uses
antihypertensive, diuretic, activates K channels and AMPA receptors
Definition
ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-).
Manufacturing Process
125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of chlorobenzene and 15 g of adipic acid dichloride are added at a temperature between 110° and 130°C drop by drop to the solution. After evolution of hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered hot with suction, washed with chlorobenzene, extracted by boiling with methanol and, for purification, dissolved in an amount of methanolic caustic soda solution required for neutralization, filtered with charcoal, and precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C (with decomposition).
brand name
Pharmaceutic necessity for Iodipamide Meglumine [Injection]. Cholografin (Bristol-Myers Squibb).
Therapeutic Function
Diagnostic aid (radiopaque medium)
Hazard
Toxic by ingestion.
IODIPAMIDESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- +49 3493/605464
- sales@intatrade.de
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 86-21-63210123
- sj_scrc@sinopharm.com
IODIPAMIDE(606-17-7)Related Product Information
- 4-IODOBENZALDEHYDE
- IODIPAMIDE
- 2,4-Diiodoaniline
- iocarmic acid
- Acetrizoic acid
- 4-IODO-3-METHYLANILINE
- ADIPAMIDE
- 2-Iodobenzoic acid
- 2-Iodobenzyl alcohol
- N-(4-Iodophenyl)acetamide
- 3-Amino-2,4,6-triiodobenzoic acid
- 4-Iodobenzyl alcohol
- 4-Iodobenzoic acid
- 2-IODO-5-METHYLANILINE
- CHEMBRDG-BB 5941601
- 2,4,6-TRIIODO-PHENYLAMINE
- 1,3,5-TRIIODOBENZENE
- ADIPIC DIANILIDE