3-methylmorpholine Chemical Properties

Boiling point:

133-134 °C

Density 

0.9591 g/cm3(Temp: 16 °C)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

9.03±0.40(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39

RIDADR 

UN2924

HazardClass 

3, 8

HS Code 

2934999090

3-methylmorpholine Usage And Synthesis

Synthesis

A solution of 4-(4-methoxybenzyl)-3-methylmorpholine (7 g, 31.53 mmol, 1.00 eq.) in methanol (70 mL) was added to a 250 mL round-bottom flask under nitrogen protection. A 10% palladium-carbon catalyst (2 g) was then added. After passing hydrogen (H2), the reaction mixture was stirred in an oil bath at 50 °C overnight. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give 2.1 g (66% yield) of 3-methylmorpholine as a yellow oil.LC-MS analysis: (ES, m/z): 102 [M + H]+.

References

[1] Patent: WO2011/28947, 2011, A2. Location in patent: Page/Page column 154; 157

3-methylmorpholine(42185-06-8)Related Product Information

• Scopolamine hydrobromide
• SCOPOLAMINE METHYL NITRATE
• tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
• Scopolamine butylbromide
• Anisodine hydrobromide
• Scopine hydrochloride
• PHENDIMETRAZINE BITARTRATE
• SCOPOLAMINE N-OXIDE HYDROBROMIDE
• HYOSCINE HYDROCHLORIDE
• Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
• Methscopolamine bromide
• Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
• tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
• 2-(4-CHLORO-PHENYL)-2-METHYL-MORPHOLINE
• DIMETHYL-MORPHOLIN-2-YLMETHYL-AMINE
• (S)-2-Methylmorpholine HCl
• 4-BENZYL-2-(CHLOROMETHYL)MORPHOLINE
• 4-(4-METHYLMORPHOLINE)BENZENEBORONIC ACID, PINACOL ESTER