Pirmenol hydrochloride Chemical Properties

Melting point:

171-172 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO : ≥ 28 mg/mL (74.68 mM)

form 

Solid

color 

White to yellow

Pirmenol hydrochloride Usage And Synthesis

Description

Pirrnenol hydrochloride is a long-lasting Class la antiarrhythmic agent introduced in Japan in 1994. The spectrum of antiarrhythmic activity of pirmenol includes atrial and ventricular arrhythmias of diverse etiology. In clinical trials, pirmenol was found effective in the short- and mid-term treatment of chronic premature ventricular beats, with or without underlying heart disease. In patients with supraventricular tachycardia, a single oral dose of pirmenol was highly effective in suppressing induction of tachycardia with adequate hemodynamic tolerance. Since pirmenol is highly effective by both intravenous and oral routes, it enables immediate suppression, prevention, or termination of cardiac arrhythmias and facilitates the transition to oral prophylactic therapy.

Originator

Warner-Lamber (U.S.A.)

Uses

Cardiac depressant (anti-arrhythmic).

brand name

Pirmavar (Parke-Davis);Plmenol.

Toxics Screening Level

The initial threshold screening level (ITSL) for pirmenol is 3 μg/m3 baaed on an annual averaging time.

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